aProximate TM PTCs maintain high expression of key transporters involved in drug handling, including megalin and cubilin, making them ideal for studying drug transporters and drug interactions with ...

Renal drug excretion involves filtration, reabsorption, and secretion, crucial for drug clearance and minimizing toxicity. The study models renal clearance using pharmacokinetic parameters, validated ...

Brivaracetam is an orphan drug for the treatment of symptomatic myoclonus. It is a novel high-affinity SV2A ligand that also displays inhibitory activity at neuronal voltage-dependent sodium channels.

A reduction in urinary citrate levels may be the mechanism underlying the higher incidence of kidney stones in patients taking PPIs, according to investigators. Individuals who use proton pump ...

Magnesium is an important cofactor for numerous enzymes. All ATPase reactions require Mg 2+ –ATP, including those involved in RNA and DNA biologic functions. It opposes calcium actions and acts as a ...

Nephrotoxicity is defined as the rapid deterioration in kidney function as a result of medications and chemicals. Nephrotoxicity can also be defined as an adverse event caused by substances that ...

New research shows combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to offer additional protection against heart ...