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  1. Depression - StatPearls - NCBI Bookshelf

    Jul 17, 2023 · Pathophysiology The underlying pathophysiology of major depressive disorder has not been clearly defined. Current evidence points to a complex interaction between …

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  2. Major depressive disorder: hypothesis, mechanism, prevention and ...

    Feb 9, 2024 · In this work, we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD, preventive approaches and therapeutic medicines, as …

  3. New insights into the molecular pathophysiology and treatment of depression

    Oct 1, 2025 · Clinical depression involves impairment of neurotransmitters like Dopamine, serotonin and norepinephrine, along with suppressed receptor sensitivity and altered …

  4. What are the Biological Mechanisms of Depression?

    Feb 12, 2025 · Depression is a mood disorder that significantly impacts brain network dynamics involved in emotional regulation, cognitive control, and self-referential processing.

  5. How Depression Changes the Brain - sciencenewstoday.org

    Aug 8, 2025 · To grasp how depression changes the brain, we must first understand the key brain regions involved in mood regulation and emotional processing. These regions work in concert, …

  6. The Pathogenesis and Medical Treatment of Depression ... - MDPI

    Aug 4, 2025 · Investigating mechanisms and developing novel, effective, well-tolerated antidepressants is crucial. This review analyzes depression pathogenesis hypotheses and …

  7. Communicating the Neurobiology of MDD | Psychiatric News

    Nov 26, 2025 · Kraus C, Castrén E, Kasper S: Serotonin and neuroplasticity—links between molecular, functional and structural pathophysiology in depression. Neurosci Biobehav Rev …

  8. The neurobiological and molecular underpinnings of depressive …

    Recent advances in molecular and cellular techniques have paved the way to better understand the pathophysiology of depression. This chapter summarizes the current knowledge of the …

  9. Depressive Disorders - Psychiatric Disorders - Merck Manual ...

    Depressive Disorders - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.

  10. The Biology of Depression: Brain Changes and Chemistry

    Jun 25, 2025 · Explore the complex biology of depression. This article examines the physiological changes in the brain and body that define it as a medical condition.